New biologically active ionic liquids with benzethonium cation-efficient SAR inducers and antimicrobial agents
Patrycja Czerwoniec
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poznań, Poland
Search for more papers by this authorRafal Kukawka
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Search for more papers by this authorMaciej Spychalski
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Search for more papers by this authorRyszard Koczura
Department of Microbiology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poznań, Poland
Search for more papers by this authorJoanna Mokracka
Department of Microbiology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poznań, Poland
Search for more papers by this authorCorresponding Author
Marcin Smiglak
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Innosil Sp. z o.o., Poznań, Poland
Correspondence to: M Smiglak, Poznan Science and Technology Park, Adam Mickiewicz University Foundation, ul. Rubiez 46, 61-612 Poznan, Poland. E-mail: [email protected]
Search for more papers by this authorPatrycja Czerwoniec
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poznań, Poland
Search for more papers by this authorRafal Kukawka
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Search for more papers by this authorMaciej Spychalski
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Search for more papers by this authorRyszard Koczura
Department of Microbiology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poznań, Poland
Search for more papers by this authorJoanna Mokracka
Department of Microbiology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poznań, Poland
Search for more papers by this authorCorresponding Author
Marcin Smiglak
Poznan Science and Technology Park, Adam Mickiewicz University Foundation, Poznań, Poland
Innosil Sp. z o.o., Poznań, Poland
Correspondence to: M Smiglak, Poznan Science and Technology Park, Adam Mickiewicz University Foundation, ul. Rubiez 46, 61-612 Poznan, Poland. E-mail: [email protected]
Search for more papers by this authorAbstract
BACKGROUND
An urgent need to find new methods for crop protection remains open due to the withdrawal from the market of the most toxic pesticides and increasing consumer awareness. One of the alternatives that can be used in modern agriculture is the use of bifunctional compounds whose actions towards plant protection are wider than those of conventional pesticides.
RESULTS
In this study, we present the investigation of the biological efficacy of nine dual-functional salts containing a systemic acquired resistance (SAR)-inducing anion and the benzethonium cation. A significant result of the presented study is the discovery of the SAR induction activity of benzethonium chloride, which was previously reported only as an antimicrobial agent. Moreover, the concept of dual functionality was proven, as the application of presented compounds in a given concentrations resulted both in the control of human and plant bacteria species and induction of SAR.
CONCLUSION
The strategy presented in this article shows the capabilities of derivatization of common biologically active compounds into their ionic derivatives to obtain bifunctional salts. This approach may be an example of the design of potential new compounds for modern agriculture. It provides plants with two complementary actions allowing to provide efficient protection to plants, if one mode of action is ineffective. © 2024 Society of Chemical Industry.
CONFLICT OF INTEREST STATEMENT
The authors declare no competing financial interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are openly available in Poznan Science and Technology Park Repository at https://ppnt.poznan.pl/repository.
Supporting Information
| Filename | Description |
|---|---|
| ps8014-sup-0001-Supinfo.docxWord 2007 document , 26.7 KB | Data S1. Nuclear magnetic resonance analysis. Data S2. SAR induction activity. Data S3. Antimicrobial activity of tested substances containing benzethonium cation. Table S1. MIC and MBC values of new derivatives. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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